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DRUG CLASS:

Serotonin 1A-2A-2B-2C receptor antagonist

24d
Enrollment open • Trial initiation date • Head-to-Head
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chlorpromazine
26d
Symptomatic hyperprolactinemia mimicking pituitary pathology in a child with Landau-Kleffner syndrome, autism spectrum disorder, and intellectual disability: a case report. (PubMed, J Med Case Rep)
The case shows the significance of following prolactin levels in children who are on risperidone therapy particularly those who are non-verbal or those who cannot communicate any discomfort. Clinicians are to remember that risperidone leads to hyperprolactinemia which can simulate pituitary malfunctions. Early identification, educating caregivers, and substitution of prolactin-stimulating drugs with prolactin-sparing ones like olanzapine will allow avoiding unnecessary investigations and enhancing the clinical and family outcomes.
Journal
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PRL (Prolactin)
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olanzapine
1m
Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice. (PubMed, Front Mol Neurosci)
Together, these findings indicate that acute treatment with risperidone in male mice exerts pronounced molecular effects in medial and ventral forebrain regions with high oligodendrocyte and glial cell abundance. Moreover, enrichment analysis points to a molecular convergence between risperidone-induced transcription and genetic pathways implicated in schizophrenia.
Preclinical • Journal
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OLIG2 (Oligodendrocyte Transcription Factor 2)
2ms
New trial
2ms
CINEMA: Cerebellum-based Imaging Neural Markers for Antipsychotic Response (clinicaltrials.gov)
P4, N=120, Recruiting, Northwell Health | Phase classification: P --> P4
Phase classification
2ms
SEP-1: Subjective Experience Following Psilocybin (clinicaltrials.gov)
P2, N=128, Recruiting, University of Calgary | Not yet recruiting --> Recruiting
Enrollment open
2ms
New trial • Head-to-Head
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chlorpromazine
2ms
Trial initiation date
2ms
New P2 trial
3ms
BEEST: Biomarkers to Enhance Early Schizophrenia Treatment (clinicaltrials.gov)
P4, N=180, Recruiting, Northwell Health | Not yet recruiting --> Recruiting
Enrollment open
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HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1)