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    DRUG CLASS:

    DLL4 inhibitor

    Related drugs:
    26d
    Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer (clinicaltrials.gov)
    P2, N=25, Not yet recruiting, Washington University School of Medicine
    New P2 trial
    |
    5-fluorouracil • irinotecan • leucovorin calcium • tovecimig (CTX-009)
    27d
    Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma (clinicaltrials.gov)
    P1/2, N=54, Recruiting, Washington University School of Medicine | Not yet recruiting --> Recruiting
    Enrollment open
    |
    IDH wild-type
    |
    tovecimig (CTX-009)
    2ms
    A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) (clinicaltrials.gov)
    P2/3, N=168, Active, not recruiting, Compass Therapeutics | Completed --> Active, not recruiting | Trial completion date: Jan 2026 --> Dec 2026 | Trial primary completion date: Jan 2026 --> Dec 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    paclitaxel • tovecimig (CTX-009)
    3ms
    A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) (clinicaltrials.gov)
    P2/3, N=168, Completed, Compass Therapeutics | Active, not recruiting --> Completed | Trial primary completion date: Jul 2025 --> Jan 2026
    Trial completion • Trial primary completion date
    |
    paclitaxel • tovecimig (CTX-009)
    5ms
    Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma (clinicaltrials.gov)
    P1/2, N=54, Not yet recruiting, Washington University School of Medicine
    New P1/2 trial
    |
    IDH wild-type
    |
    tovecimig (CTX-009)
    1year
    COMPANION-003: A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer (clinicaltrials.gov)
    P2, N=49, Completed, Compass Therapeutics | Active, not recruiting --> Completed | N=84 --> 49
    Trial completion • Enrollment change
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability)
    |
    HER-2 positive • BRAF V600E • MSI-H/dMMR • BRAF V600
    |
    tovecimig (CTX-009)
    over1year
    COMPANION-003: A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer (clinicaltrials.gov)
    P2, N=84, Active, not recruiting, Compass Therapeutics | Trial completion date: Dec 2024 --> Jun 2025 | Trial primary completion date: Jun 2024 --> Mar 2025
    Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability)
    |
    HER-2 positive • BRAF V600E • MSI-H/dMMR • BRAF V600
    |
    tovecimig (CTX-009)
    over1year
    CTX-009 with Gemcitabine, Cisplatin, and Durvalumab As First-line Therapy in Patients with Unresectable or Metastatic Biliary Tract Cancers (clinicaltrials.gov)
    P1/2, N=50, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open
    |
    cisplatin • Imfinzi (durvalumab) • gemcitabine • tovecimig (CTX-009)
    over1year
    A Study of CTX-009 (ABL001) in Combination With Irinotecan or Paclitaxel in Advanced or Metastatic Solid Tumor Patients (clinicaltrials.gov)
    P1/2, N=41, Terminated, Handok Inc. | N=92 --> 41 | Trial completion date: Jul 2025 --> Jan 2025 | Active, not recruiting --> Terminated; Change of Development Plan
    Enrollment change • Trial completion date • Trial termination
    |
    paclitaxel • irinotecan • tovecimig (CTX-009)
    almost2years
    A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) (clinicaltrials.gov)
    P2/3, N=150, Active, not recruiting, Compass Therapeutics | Recruiting --> Active, not recruiting
    Enrollment closed • Combination therapy • Metastases
    |
    paclitaxel • tovecimig (CTX-009)
    almost2years
    CTX-009 With Gemcitabine, Cisplatin, and Durvalumab as First-line Therapy in Patients With Unresectable or Metastatic Biliary Tract Cancers (clinicaltrials.gov)
    P1/2, N=50, Not yet recruiting, M.D. Anderson Cancer Center
    New P1/2 trial • Metastases
    |
    cisplatin • Imfinzi (durvalumab) • gemcitabine • tovecimig (CTX-009)
    over2years
    COMPANION-003: A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer (clinicaltrials.gov)
    P2, N=84, Active, not recruiting, Compass Therapeutics | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability)
    |
    HER-2 positive • BRAF V600E • MSI-H/dMMR • BRAF V600
    |
    tovecimig (CTX-009)