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BIOMARKER:
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
i
Other names:
HEL-216, HEL-S-26, Epididymis Luminal Protein 216, Isocitrate Dehydrogenase 1 (NADP+), Epididymis Secretory Protein Li 26, IDH1, Isocitrate Dehydrogenase (NADP(+)) 1, Isocitrate Dehydrogenase 1 (NADP+), Soluble, DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
;
3417
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
IDH1 mutation (79)
MET exon 14 mutation (33)
MET mutation (13)
IDH1 R132H (9)
IDH1 R132C (5)
MET H1094Y (3)
MET N375S (3)
IDH1 R132 (3)
IDH wild-type (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
MET F1200I (2)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR T790M + MET mutation (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 mutation + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 rs1437410 (1)
MET D1228H (0)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
IDH1 mutation (79)
MET exon 14 mutation (33)
MET mutation (13)
IDH1 R132H (9)
IDH1 R132C (5)
MET H1094Y (3)
MET N375S (3)
IDH1 R132 (3)
IDH wild-type (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
MET F1200I (2)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR T790M + MET mutation (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 mutation + TP53 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 rs1437410 (1)
MET D1228H (0)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
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IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
Anaplastic Astrocytoma
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
Anaplastic Astrocytoma
carboplatin + temozolomide + vincristine
Resistant: C4 – Case Studies
carboplatin + temozolomide + vincristine
Resistant
:
C4
carboplatin + temozolomide + vincristine
Resistant: C4 – Case Studies
carboplatin + temozolomide + vincristine
Resistant
:
C4
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