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    Association details:
    Biomarker:HER-2 expression
    Cancer:Biliary Tract Cancer
    Drug:anvatabart opadotin (JNJ-0683) (Microtubule inhibitor, HER2-targeted antibody-drug conjugate)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    Source:
    clinicaltrialsregister.eu
    Title:

    Clinical study on the efficacy and safety of ARX788 in combination with toripalimab in patients with HER2-expressing or mutant advanced solid tumors.

    Excerpt:
    ......
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    Ambrx Press Release
    Title:

    Ambrx Presents Phase 1 Trial Data Update and Phase 2/3 Clinical Trial in Progress for Lead Program ARX788 at the 2020 San Antonio Breast Cancer Symposium

    Published date:
    12/10/2020
    Excerpt:
    ORR of 67% (2/3) and DCR of 100% in the 1.5 mg/kg cohort of Phase 1 HER2-positive pan tumor trial in U.S. and Australia...which enrolled patients with HER2 expressing cancers including breast cancer, gastric/gastroesophageal junction adenocarcinoma, non-small cell lung cancer, bladder, colorectal, biliary track, and salivary gland cancers in US and Australia.