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    Association details:
    Biomarker:ER positive
    Cancer:HER2 Negative Breast Cancer
    Drug:Etcamah (camizestrant) (Estrogen receptor antagonist, Selective estrogen receptor degrader)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    Go to data
    Source:
    clinicaltrials.gov
    Title:

    Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer (SERENA-1)

    Excerpt:
    Documented positive oestrogen receptor status of primary or metastatic tumour tissue, according to the local laboratory parameters. HER-2 negative.
    Trial ID:
    SERENA-1
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    ASCO 2020
    Title:

    A phase I dose escalation and expansion study of the next generation oral SERD AZD9833 in women with ER-positive, HER2-negative advanced breast cancer.

    Published date:
    05/13/2020
    Excerpt:
    AZD9833 has an encouraging efficacy and dose-dependent safety profile. Evidence of clinical benefit and target engagement was observed at all dose levels in women with ER+ ABC…
    DOI:
    10.1200/JCO.2020.38.15_suppl.1024
    Trial ID:
    SERENA-1
    Pictures: